This brand of Resveratrol has been well tolerated by my wife and I.We started 2 yrs ago with Resveratrol + Nad supplements. We have used many brands and doses, many times the price of this one in particular. This brand has never let us down! I used this supplement and others to overcome cancer and Liver disease. I have energy -strengthand alertness. Its helped me with weight loss also. I am 58 yrs old and somedays I have the ability to experience youthfulness again, real energy in a word - Energized .. "If you want your life to change - change things in your life"!!! I wish you health Be well Doug